PTEN Deficiency Mediates a Reciprocal Response to IGFI and mTOR Inhibition
نویسندگان
چکیده
منابع مشابه
PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition.
UNLABELLED Recent evidence implicates the insulin-like growth factor (IGF) pathway in development of Ewing sarcoma, a highly malignant bone and soft-tissue tumor that primarily affects children and young adults. Despite promising results from preclinical studies of therapies that target this pathway, early-phase clinical trials have shown that a significant fraction of patients do not benefit, ...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2014
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-14-0006